abstract：:Nonspecific vasodilatation during iontophoresis is an important confounding factor in experimental pharmacology. In this investigation, we studied the involvement of sensory nerves and histamine-related reactions in causing nonspecific vasodilatation in a model of anodal and cathodal iontophoresis of sodium chloride. ...

journal_title：Microvascular research

authors： Horiuchi Y,Droog EJ,Henricson J,Wikström T,Lennquist S,Sjöberg F

更新日期：2004-03-01 00:00:00

abstract：:Reperfusion of the ischemic lung is associated with increased pulmonary vascular resistance and reduced alveolar perfusion in conjunction with an inflammatory response. To determine the contribution of platelet-endothelial interactions, we examined effects of pulmonary ischemia-reperfusion (IR) on platelet adhesion an...

journal_title：Microvascular research

authors： Roberts AM,Ovechkin AV,Mowbray JG,Robinson TW,Lominadze D

更新日期：2004-01-01 00:00:00

abstract：:Rho-associated kinases are involved in regulation of actin-myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells. By influencing the contraction of the intraendothelial filaments, Rho kinases may affect the size of the interendothelial gaps and thereby influenc...

journal_title：Microvascular research

authors： Lundblad C,Bentzer P,Grände PO

更新日期：2003-09-01 00:00:00

abstract：:The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to ischemia-reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic...

journal_title：Microvascular research

authors： Sun CK,Zhang XY,Wheatley AM

更新日期：2003-07-01 00:00:00

abstract：:Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control of body weight. Recently, leptin was found to be an angiogenic factor, and its vitreous levels are associated with angiogenic eye diseases such as proliferative diabetic retinopathy. However, the molecular mechanism for lept...

journal_title：Microvascular research

authors： Yamagishi S,Amano S,Inagaki Y,Okamoto T,Takeuchi M,Inoue H

更新日期：2003-05-01 00:00:00

abstract：:The angiopoietin/Tie2 system is a predominant regulator of vascular development. This vascular development appears to be controlled and completed by the coordinated actions of two vascular cells, endothelial cells and their surrounding supporting cells, smooth muscle cells, or pericytes. The role of the angiopoietin/T...

journal_title：Microvascular research

authors： Park YS,Kim NH,Jo I

更新日期：2003-03-01 00:00:00

abstract：:Recent studies indicate that the human choroid has a considerable capacity to keep blood flow constant despite exercise-induced increases in perfusion pressure. The mechanisms underlying this vasoconstrictor response remain unclear. We hypothesized that pharmacological modulation of the autonomic nervous system may al...

journal_title：Microvascular research

authors： Polska E,Luksch A,Schering J,Frank B,Imhof A,Fuchsjäger-Mayrl G,Wolzt M,Schmetterer L

更新日期：2003-01-01 00:00:00

abstract：:Diffusion of oxyhemoglobin has been shown to augment the oxygen transport inside the red blood cells. Measurement of hemoglobin diffusion coefficients by pulsed-field gradient (PFG) nuclear magnetic resonance (NMR) technique can be used for estimating this augmentation effect. Self-diffusion coefficients of polymerize...

journal_title：Microvascular research

authors： Budhiraja V,Hellums JD,Post JF

更新日期：2002-11-01 00:00:00

abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...

journal_title：Microvascular research

authors： Buerk DG,Riva CE

更新日期：2002-09-01 00:00:00

abstract：:The size of hyaluronan in lymph and gastrocnemius muscle was measured to test the hypothesis that reperfusion of ischemic skeletal muscle leads to hyaluronan depolymerization. Prenodal lymph was collected from the gastrocnemius muscle in anesthetized rabbits. Hyaluronan size was measured using a combination of agarose...

journal_title：Microvascular research

authors： Armstrong SE,Bell DR

更新日期：2002-09-01 00:00:00

abstract：:The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...

journal_title：Microvascular research

authors： Weber E,Rossi A,Solito R,Sacchi G,Agliano' M,Gerli R

更新日期：2002-07-01 00:00:00

abstract：:The main objective of this study was to identify molecular mechanisms through which angiopoietin-1 (Ang-1), a ligand for Tie-2 receptors, influences endothelial cell apoptosis. Human umbilical vein endothelial cells were cultured in a medium enriched with 2% fetal bovine serum (FBS) and growth supplements. Apoptosis w...

journal_title：Microvascular research

authors： Harfouche R,Hasséssian HM,Guo Y,Faivre V,Srikant CB,Yancopoulos GD,Hussain SN

更新日期：2002-07-01 00:00:00

abstract：:Angiogenesis is widely accepted to play a central role in tumor growth and spreading. Therefore, anti-angiogenic agents appear as promising tools in cancer therapy, and great efforts have been devoted to their identification in recent years. Despite fast progress in this area, a quantitative and objective system for r...

journal_title：Microvascular research

authors： Sanz L,Pascual M,Muñoz A,González MA,Salvador CH,Alvarez-Vallina L

更新日期：2002-05-01 00:00:00

abstract：:We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...

journal_title：Microvascular research

authors： Varma S,Breslin JW,Lal BK,Pappas PJ,Hobson RW 2nd,Durán WN

更新日期：2002-03-01 00:00:00

abstract：:In previous studies, the flow of albumin solution through hydrated lung interstitial segments was higher than a prior flow of Ringer solution (A. Tajaddinni et al., 1994, J. Appl. Physiol. 76, 578-583). We wondered whether this effect was caused by an increased pore size. We measured the flow of albumin solutions thro...

journal_title：Microvascular research

authors： Villarruel S,Ibbott GS,Lai-Fook SJ

更新日期：2002-01-01 00:00:00

abstract：:This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. Gracilis arteries (GA) were viewed via television microscopy and constrictor responses to elevated P...

journal_title：Microvascular research

authors： Frisbee JC,Krishna UM,Falck JR,Lombard JH

更新日期：2001-11-01 00:00:00

abstract：:We investigated the expression of cell adhesion molecules on the surface of glomerular endothelial cells (GEC), dermal microvascular endothelial cells (MvE), and umbilical vein endothelial cells (HUVEC) that had or had not been stimulated by cytokines. PECAM-1 was constitutively expressed at a high level on HUVEC but ...

journal_title：Microvascular research

authors： Murakami S,Morioka T,Nakagawa Y,Suzuki Y,Arakawa M,Oite T

更新日期：2001-11-01 00:00:00

abstract：:To investigate the relevance of *NO and oxyradicals in the blood-brain barrier (BBB), differentiated and well-proliferating brain capillary endothelial cells (BCEC) are required. Therefore, rat BCEC (rBCEC) were transfected with immortalizing genes. The resulting lines exhibited endothelial characteristics (factor VII...

journal_title：Microvascular research

authors： Blasig IE,Giese H,Schroeter ML,Sporbert A,Utepbergenov DI,Buchwalow IB,Neubert K,Schönfelder G,Freyer D,Schimke I,Siems WE,Paul M,Haseloff RF,Blasig R

更新日期：2001-09-01 00:00:00

abstract：:We have developed an intensity analysis technique for fluorescence microscopy that allows us to measure, in real time, the diameter and the membrane potential or intracellular calcium ([Ca(2+)]i) of in vivo arteriolar endothelium or smooth muscle. Cheek pouch arterioles of anesthetized hamsters were luminally or ablum...

journal_title：Microvascular research

authors： Chen Y,Rivers RJ

更新日期：2001-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) was originally discovered as vascular permeability factor because of its ability to increase microvascular permeability to plasma proteins. Since then, it has been shown to induce proliferation and migration in endothelial cells. Placenta growth factor (PlGF) is a member of th...

journal_title：Microvascular research

authors： Dull RO,Yuan J,Chang YS,Tarbell J,Jain RK,Munn LL

更新日期：2001-03-01 00:00:00

abstract：:We tested the hypothesis that the endothelial nitric oxide (NO)-soluble guanylyl cyclase system is involved in atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) mediated regulation of coronary and peripheral vascular resistance. Rat hearts were perfused via the aorta at constant flow and the effect...

journal_title：Microvascular research

authors： Brunner F,Wölkart G

更新日期：2001-01-01 00:00:00

abstract：:Using the laser-Doppler method we measured blood flow on the nailfold skin to compare the reactivity of cutaneous microcirculation in three groups of normotensive subjects: 11 subjects with a familial predisposition to hypertension without a previous record of high blood pressure, 6 predisposed subjects with a previou...

journal_title：Microvascular research

authors： Maver J,Strucl M

更新日期：2000-11-01 00:00:00

abstract：:The purpose of this study was to determine if there are intrinsic differences in resting tone, vascular reactivity, myogenic responses, and neurogenic vasoconstriction between the large and small feeder arteries and first order arterioles (1A) of the rat cremaster muscle. The pudic-epigastric artery (PEA), external sp...

journal_title：Microvascular research

authors： Sylvester FA,Frisbee JC,Lombard JH

更新日期：2000-09-01 00:00:00

abstract：:The aim of this study was to evaluate whether streptokinase (SK) may produce beneficial effects at the level of microvascular circulation in addition to coronary recanalization. Twenty mongrel dogs weighing 28.4 +/- 4.6 kg were randomized to receive SK (16,000-72,000 U/kg) or 20 ml saline (control) in an open-chest an...

journal_title：Microvascular research

authors： Woo KS,Armiger LC,White HD,Norris RM

更新日期：2000-07-01 00:00:00

abstract：:Angiotensin II is considered to have angiogenic properties. Nevertheless, several authors reported an increase in coronary capillary density after treatment with ACE inhibitors. The aim of the present study was to evaluate the effect of treatment with low doses of ACE inhibitor perindopril, low doses of the diuretic i...

journal_title：Microvascular research

authors： Rakusan K,Cicutti N,Maurin A,Guez D,Schiavi P

更新日期：2000-03-01 00:00:00

abstract：:Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...

journal_title：Microvascular research

authors： Hudlická O,Brown MD,Silgram H

更新日期：2000-01-01 00:00:00

abstract：:Pericytes are known to communicate with endothelial cells by direct contact and by releasing cytokines such as TGF-beta. There is also strong evidence that pericytes act as regulators of endothelial cell proliferation and differentiation. We have investigated the effect of pericyte-conditioned medium (PCM) on prolifer...

journal_title：Microvascular research

authors： Martin AR,Bailie JR,Robson T,McKeown SR,Al-Assar O,McFarland A,Hirst DG

更新日期：2000-01-01 00:00:00

abstract：:In this paper we quantitatively investigate the hypothesis proposed by Michel (Exp. Physiol. 82, 1-30, 1997) and Weinbaum (Ann. Biomed. Eng. 26, 1-17, 1998) that the Starling forces are determined by the local difference in the hydrostatic and colloid osmotic pressure across the endothelial surface glycocalyx, which w...

journal_title：Microvascular research

authors： Hu X,Weinbaum S

更新日期：1999-11-01 00:00:00

abstract：:The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...

journal_title：Microvascular research

authors： Higaki T,Sawada S,Kono Y,Imamura H,Tada Y,Yamasaki S,Toratani A,Sato T,Komatsu S,Akamatsu N,Tamagaki T,Tsuda Y,Tsuji H,Nakagawa M

更新日期：1999-09-01 00:00:00

abstract：:Patients with diabetic polyneuropathy are known to have an impaired neurovascular reflex arc compared to healthy controls. This is seen in a delayed decrease in microcirculation of the ipsilateral hand after cooling of the contralateral hand. The aim of this pilot study was to investigate whether intravenous alpha-lip...

journal_title：Microvascular research

authors： Haak ES,Usadel KH,Kohleisen M,Yilmaz A,Kusterer K,Haak T

更新日期：1999-07-01 00:00:00

abstract：:Failure of the glomerular barrier causing proteinuria has been modeled chiefly by Chang, Deen, and Brenner. They have refined models from an isoporous filter to a mostly isoporous membrane, which during proteinuric disease opens up nondiscriminating shunts. This report extends these concepts by measuring a larger dist...

journal_title：Microvascular research

authors： Katz MA,Schaeffer RC Jr,Gratrix M,Mucha D,Cárbajal J

更新日期：1999-05-01 00:00:00

abstract：:In preeclampsia, invasion of intrauterine decidual blood vessels by placental cytotrophoblasts is significantly reduced. This study examined the secretion of matrix metalloproteinases (MMP) by cultured human decidual endothelial cells from normal (NDEC) and preeclamptic (PEDEC) pregnancies. MMPs secreted into the cult...

journal_title：Microvascular research

authors： Gallery ED,Campbell S,Arkell J,Nguyen M,Jackson CJ

更新日期：1999-05-01 00:00:00

abstract：:Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix (ECM) are of central importance to vascular growth. Here, we present a new model of EC migration and morphogenesis within three-dimensional ECM termed "radial invasion of matrix by aggregated cells" (RIMAC). In the RIMAC model,...

journal_title：Microvascular research

authors： Vernon RB,Sage EH

更新日期：1999-03-01 00:00:00

abstract：:We studied the absorbing peripheral lymphatic vessel with the light microscope, the transmission electron microscope, the scanning electron microscope, and three-dimensional models of the diaphragm of several rodents and insectivores under normal and experimental conditions (lymphatic stasis and dehydration). To clari...

journal_title：Microvascular research

authors： Azzali G

更新日期：1999-01-01 00:00:00

abstract：:Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...

journal_title：Microvascular research

authors： Frisbee JC,Lombard JH

更新日期：1998-11-01 00:00:00

abstract：:Lipopolysaccharide released during bacterial sepsis causes acute lung injury and ARDS. Pulmonary microvascular injury is a feature of ARDS, and vascular remodeling develops, leading to pulmonary hypertension. Pericytes in the lung circulation proliferate and contribute to the remodeling seen in experimental sepsis. It...

journal_title：Microvascular research

authors： Khoury J,Langleben D

更新日期：1998-09-01 00:00:00

abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...

journal_title：Microvascular research

authors： Schönfelder U,Hofer A,Paul M,Funk RH

更新日期：1998-07-01 00:00:00

abstract：:In a novel assay of angiogenesis in the quail chorioallantoic membrane (CAM), we measured vascular pattern and angiogenic rate after homogeneous exposure of the entire vascular tree to recognized modulators of vessel growth. In comparison to phosphate-buffered saline (PBS)-treated controls, the vascular stimulator, ba...

journal_title：Microvascular research

authors： Parsons-Wingerter P,Lwai B,Yang MC,Elliott KE,Milaninia A,Redlitz A,Clark JI,Sage EH

更新日期：1998-05-01 00:00:00

abstract：:The dynamics of the microvasculature of the blood-perfused canine gastrocnemius-plantaris muscle in situ at rest and during contraction were determined using multiple-indicator dilution analysis. Permeability-surface area product (PS) was estimated using a bolus indicator dilution of 86Rb, with 125I-albumin serving as...

journal_title：Microvascular research

authors： Frisbee JC,Barclay JK

更新日期：1998-03-01 00:00:00

abstract：:An increased recognition of the role of endothelial cells in disease and the development of methods for endothelial cell culture has led to an upsurge in in vitro studies of endothelial cell function. However, the cells most often used for these studies do not reflect the in vivo heterogeneity of endothelial cells. To...

journal_title：Microvascular research

authors： Craig LE,Spelman JP,Strandberg JD,Zink MC

更新日期：1998-01-01 00:00:00